Publications
Hart TM, Sonnert ND, Tang X, Chaurasia R, Allen PE … Carlyon JA, Palm NW, Fikrig E, Ring AM. (2024). An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms. Cell, 187(15): 4113-4127.
Johnson EE*, Hart TM, Fikrig E. (2024). Vaccination to prevent Lyme disease: A movement towards anti-tick approaches. J Infect Dis, In press.
Pine M, Arora G, Hart TM, Bettini E, Gaudette BT … Pardi N. (2023). Development of an mRNA-lipid nanoparticle vaccine against Lyme disease. Mol Ther, 31(9): 2702-2714.
Marcinkiewicz AL, Brangulis K, Dupuis AP, Hart TM, Zamba-Campero M … Kolokotronis SO, Lin YP. (2023). Structural evolution of an immune evasion determinant shapes pathogen host tropism. Proc Natl Acad Sci, 120(27): e2301549120.
Tang X, Arora G, Matias J, Hart TM, Cui Y, Fikrig E. (2022). A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γ. Cell Rep, 41(8): 111673.
Hart TM, Dupuis A, Tufts DM, Blom AM, Starkey S … Lin YP. (2021). Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system. PLoS Pathog, 17(7): e1009801.
Marcinkiewicz AL, Lieknina I, Yang X, Lederman PL, Hart TM … Lin YP. (2020). The factor H-binding site of CspZ as a protective target against multistrain, tick-transmitted Lyme disease. Infect Immun, 88(5): e00956-19.
Frye AM, Hart TM, Tufts DM, Ram S, Diuk-Wasser MA … Lin YP. (2020). A soft tick Ornithodoros moubata salivary protein OmCI is a potent inhibitor to prevent avian complement activation. Tick Tick Born Dis, 11(2):101354.
Lin YP, Yu Y, Marcinkiewicz AL, Lederman P, Hart TM, Zhang F, Linhardt RJ. (2020). Non-anticoagulant heparin as a pre-exposure prophylaxis prevents Lyme disease infection. ACS Infect Dis, 6(3):503-514.
Tufts DM^, Hart TM^, Chen GF, Kolokotronis SO, Diuk-Wasser MA, Lin YP. (2019). Outer surface protein polymorphisms linked to host-spirochete association in Lyme borreliae. Mol Microbiol, 111: 868-882. ^Contributed equally to this work
Hart T, Nguyen NTT, Nowak NA, Zhang F, Linhardt RJ … Lin YP. (2018). Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission. PLOS Pathogens, 14(5): e1007106.
Hart T, Yang X, Pal U, Lin YP. (2018). Identification of Lyme borreliae proteins promoting vertebrate host blood-specific spirochete survival in Ixodes scapularis nymphs using artificial feeding chambers. Ticks Tick Borne Dis, 9(5): 1057-1063.